Product Details
Hardcover: 576 pages
Publisher: Humana Press; 1 edition (December 5, 2003)
Language: English
ISBN-10: 1588290921
ISBN-13: 978-1588290922
Product Dimensions: 9.1 x 6.3 x 1.2 inches
Shipping Weight: 2.1 pounds

Editorial Reviews
Review"...as the book provides as comprehensive collection of clear, detailed methods it is very likely to prove its worth as a laboratory reference." - Immunology News"...a valuable addition to in-lab books" - Microbiology Today Product DescriptionA core collection of diverse cutting-edge techniques for the generation, expression, optimization, and characterization of recombinant antibodies. Readily reproducible protocols for lead generation range from the cloning of human immunoglobulin genes to the selection and generation of human recombinant antibodies by humanization approaches, molecular display technologies and transgenic animals. Procedures are also described on restructuring antibody leads into monovalent, multivalent, and bispecific binding fragments for a wide variety of in vivo applications. State-of-the-art technologies are described for the characterization of antigen-binding affinity and specificity with novel applications in radioimmunotargeting, cancer immunotherapy, drug abuse, and proteomics.

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